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Clinical relevance of the CTLA-4 protein in cats with mammary carcinoma

A study developed in CIISA was noticed at site of Associação  Portuguesa de Investigação em Cancro (ASPIC). Previous studies recognized that Cytotoxic T Lymphocyte Associated Antigen 4 (CTLA-4)  has an important role in breast cancer progression, which has led to the development of novel immunotherapies aimed at blocking tumor immune evasion. Although feline mammary carcinoma is increasingly  recognized as a valuable cancer model, no studies on CTLA-4 function had been conducted in this species. The serum CTLA-4, TNF-α and IL-6 levels of 57 female cats with mammary carcinoma were determined by ELISA, and immunohistochemistry was performed to evaluate CTLA-4 and FoxP3 expression in tumor cells and interstitial lymphocytes. The clinical value and the use of the serum CTLA-4 as a diagnostic marker was  exploited in detail.


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